HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain

Dysregulation of brain iron levels causes functional disturbances and damages neurons. Hepcidin (a peptide hormone) plays a principal role in regulating intracellular iron levels by modulating ferroportin (FPN, the only known iron exporter) through triggering its internalization and lysosomal degrad...

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Detalles Bibliográficos
Autores principales: Davaanyam, Dashdulam, Lee, Hahnbi, Seol, Song-I, Oh, Sang-A, Kim, Seung-Woo, Lee, Ja-Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689467/
https://www.ncbi.nlm.nih.gov/pubmed/37907744
http://dx.doi.org/10.1038/s12276-023-01111-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689467/
https://www.ncbi.nlm.nih.gov/pubmed/37907744
http://dx.doi.org/10.1038/s12276-023-01111-z

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