Utility and greenness appraisal of nuclear magnetic resonance for sustainable simultaneous determination of three 1,4-benzodiazepines and their main impurity 2-amino-5-chlorobenzophenone

A robust, stability-indicating, and eco-friendly proton nuclear magnetic resonance ((1)H-qNMR) method was developed for the concurrent determination of three 1,4-benzodiazepines (BDZs), namely diazepam (DZP), alprazolam (ALP), and chlordiazepoxide (CDP) and their common impurity, synthesis precursor...

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Detalles Bibliográficos
Autores principales: Qandeel, Nermeen A., El-Masry, Amal A., El-Shaheny, Rania, Eid, Manal, Moustafa, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689731/
https://www.ncbi.nlm.nih.gov/pubmed/38036558
http://dx.doi.org/10.1038/s41598-023-48416-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689731/
https://www.ncbi.nlm.nih.gov/pubmed/38036558
http://dx.doi.org/10.1038/s41598-023-48416-7

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