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IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzym...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689778/ https://www.ncbi.nlm.nih.gov/pubmed/37907740 http://dx.doi.org/10.1038/s12276-023-01106-w |