IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis

Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzym...

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Detalles Bibliográficos
Autores principales: Liang, Li, Zhang, Fengmei, Feng, Naibo, Kuang, Biao, Fan, Mengtian, Chen, Cheng, Pan, Yiming, Zhou, Pengfei, Geng, Nana, Li, Xingyue, Xian, Menglin, Deng, Lin, Li, Xiaoli, Kuang, Liang, Luo, Fengtao, Tan, Qiaoyan, Xie, Yangli, Guo, Fengjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689778/
https://www.ncbi.nlm.nih.gov/pubmed/37907740
http://dx.doi.org/10.1038/s12276-023-01106-w

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