Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype

Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene-indolinones reported to bind the autophagy-related LC3B-prot...

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Detalles Bibliográficos
Autores principales: Xue, Gang, Xie, Jianing, Hinterndorfer, Matthias, Cigler, Marko, Dötsch, Lara, Imrichova, Hana, Lampe, Philipp, Cheng, Xiufen, Adariani, Soheila Rezaei, Winter, Georg E., Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689823/
https://www.ncbi.nlm.nih.gov/pubmed/38036533
http://dx.doi.org/10.1038/s41467-023-43657-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689823/
https://www.ncbi.nlm.nih.gov/pubmed/38036533
http://dx.doi.org/10.1038/s41467-023-43657-6

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