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Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene-indolinones reported to bind the autophagy-related LC3B-prot...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689823/ https://www.ncbi.nlm.nih.gov/pubmed/38036533 http://dx.doi.org/10.1038/s41467-023-43657-6 |