Dynamic RBM47 ISGylation confers broad immunoprotection against lung injury and tumorigenesis via TSC22D3 downregulation

ISGylation is a well-established antiviral mechanism, but its specific function in immune and tissue homeostasis regulation remains elusive. Here, we reveal that the RNA-binding protein RBM47 undergoes phosphorylation-dependent ISGylation at lysine 329 to regulate immune activation and maintain lung...

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Detalles Bibliográficos
Autores principales: Ding, Shihui, Pang, Xiquan, Luo, Shaoxiang, Gao, Huili, Li, Bo, Yue, Junqiu, Chen, Jian, Hu, Sheng, Tu, Zepeng, He, Dong, Kuang, Youyi, Dong, Zhiqiang, Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689852/
https://www.ncbi.nlm.nih.gov/pubmed/38036512
http://dx.doi.org/10.1038/s41420-023-01736-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689852/
https://www.ncbi.nlm.nih.gov/pubmed/38036512
http://dx.doi.org/10.1038/s41420-023-01736-z

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