Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer’s disease mutations

Disinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism remains unknown. Here we show that, in mouse lines carrying Alzheimer's disease-related mutat...

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Detalles Bibliográficos
Autores principales: Keramidis, Iason, McAllister, Brendan B, Bourbonnais, Julien, Wang, Feng, Isabel, Dominique, Rezaei, Edris, Sansonetti, Romain, Degagne, Phil, Hamel, Justin P, Nazari, Mojtaba, Inayat, Samsoon, Dudley, Jordan C, Barbeau, Annie, Froux, Lionel, Paquet, Marie-Eve, Godin, Antoine G, Mohajerani, Majid H, De Koninck, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690023/
https://www.ncbi.nlm.nih.gov/pubmed/37551444
http://dx.doi.org/10.1093/brain/awad250

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