Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine Gliomas

Diffuse intrinsic pontine gliomas (DIPG) are an incurable childhood brain cancer for which novel treatments are needed. DIPGs are characterized by a mutation in the H3 histone (H3K27M), resulting in loss of H3K27 methylation and global gene dysregulation. TRX-E-009–1 is a novel anticancer agent with...

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Detalles Bibliográficos
Autores principales: Ehteda, Anahid, Khan, Aaminah, Rajakumar, Gayathiri, Vanniasinghe, Anne S., Gopalakrishnan, Anjana, Liu, Jie, Tsoli, Maria, Ziegler, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690044/
https://www.ncbi.nlm.nih.gov/pubmed/37683275
http://dx.doi.org/10.1158/1535-7163.MCT-23-0179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690044/
https://www.ncbi.nlm.nih.gov/pubmed/37683275
http://dx.doi.org/10.1158/1535-7163.MCT-23-0179

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