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Progressive degeneration in a new Drosophila model of Spinocerebellar Ataxia type 7

Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder resulting from abnormal expansion of polyglutamine (polyQ) in its disease protein, ataxin-7 (ATXN7). ATXN7 is part of Spt-Ada-Gcn5 acetyltransferase (SAGA), an evolutionarily conserved transcriptional coactivation compl...

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Detalles Bibliográficos
Autores principales: Sujkowski, Alyson L., Ranxhi, Bedri, Prifti, Matthew V., Alam, Nadir, Todi, Sokol V., Tsou, Wei-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690306/
https://www.ncbi.nlm.nih.gov/pubmed/38045332
http://dx.doi.org/10.21203/rs.3.rs-3592641/v1