APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release

Sequential proteolysis of the amyloid precursor protein (APP) by γ‐secretases generates amyloid‐β (Aβ) peptides and defines the proportion of short‐to‐long Aβ peptides, which is tightly connected to Alzheimer's disease (AD) pathogenesis. Here, we study the mechanism that controls substrate proc...

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Detalles Bibliográficos
Autores principales: Koch, Matthias, Enzlein, Thomas, Chen, Shu‐Yu, Petit, Dieter, Lismont, Sam, Zacharias, Martin, Hopf, Carsten, Chávez‐Gutiérrez, Lucía
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690472/
https://www.ncbi.nlm.nih.gov/pubmed/37853914
http://dx.doi.org/10.15252/embj.2023114372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690472/
https://www.ncbi.nlm.nih.gov/pubmed/37853914
http://dx.doi.org/10.15252/embj.2023114372

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