GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia

BACKGROUND: Acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation accounts for a large proportion of AML patients and diagnosed with poor prognosis. Although the prognosis of FLT3-ITD AML has been greatly improved, the drug resistance frequently...

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Detalles Bibliográficos
Autores principales: Xiao, Xinhua, Wang, Peihong, Zhang, Weina, Wang, Jiayi, Cai, Mansi, Jiang, Hua, Wu, Yingli, Shan, Huizhuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691066/
https://www.ncbi.nlm.nih.gov/pubmed/38037057
http://dx.doi.org/10.1186/s12935-023-03142-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691066/
https://www.ncbi.nlm.nih.gov/pubmed/38037057
http://dx.doi.org/10.1186/s12935-023-03142-y

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