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Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure

Extracellular amyloid-β (Aβ) plaques and intracellular aggregates of tau protein in form of neurofibrillary tangles (NFT) are pathological hallmarks of Alzheimer’s disease (AD). The exact mechanism how these two protein aggregates interact in AD is still a matter of debate. Neuritic plaques (NP), a...

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Detalles Bibliográficos
Autores principales: Tsering, Wangchen, Hery, Gabriela P., Phillips, Jennifer L., Lolo, Kiara, Bathe, Tim, Villareal, Jonathan A., Ruan, Isabelle Y., Prokop, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691154/
https://www.ncbi.nlm.nih.gov/pubmed/38037144
http://dx.doi.org/10.1186/s40478-023-01688-6