Cargando…
Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure
Extracellular amyloid-β (Aβ) plaques and intracellular aggregates of tau protein in form of neurofibrillary tangles (NFT) are pathological hallmarks of Alzheimer’s disease (AD). The exact mechanism how these two protein aggregates interact in AD is still a matter of debate. Neuritic plaques (NP), a...
Autores principales: | Tsering, Wangchen, Hery, Gabriela P., Phillips, Jennifer L., Lolo, Kiara, Bathe, Tim, Villareal, Jonathan A., Ruan, Isabelle Y., Prokop, Stefan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691154/ https://www.ncbi.nlm.nih.gov/pubmed/38037144 http://dx.doi.org/10.1186/s40478-023-01688-6 |
Ejemplares similares
-
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
por: Delizannis, Argyro Thalia, et al.
Publicado: (2021) -
TREM2 function impedes tau seeding in neuritic plaques
por: Leyns, Cheryl E.G., et al.
Publicado: (2019) -
The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model
por: Li, Tong, et al.
Publicado: (2016) -
Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
por: Ly, Philip T.T., et al.
Publicado: (2011) -
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
por: Laversenne, Vanessa, et al.
Publicado: (2020)