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TGF-β broadly modifies rather than specifically suppresses reactivated memory CD8 T cells in a dose-dependent manner
Transforming growth factor β (TGF-β) directly acts on naive, effector, and memory T cells to control cell fate decisions, which was shown using genetic abrogation of TGF-β signaling. TGF-β availability is altered by infections and cancer; however, the dose-dependent effects of TGF-β on memory CD8 T...
Autores principales: | Taber, Alexis, Konecny, Andrew, Oda, Shannon K., Scott-Browne, James, Prlic, Martin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691214/ https://www.ncbi.nlm.nih.gov/pubmed/37988468 http://dx.doi.org/10.1073/pnas.2313228120 |
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