Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques

Introduction: Misfolding of amyloidogenic proteins is a molecular hallmark of neurodegenerative diseases in humans. A detailed understanding of the underlying molecular mechanisms is mandatory for developing innovative therapeutic approaches. The bovine PI3K-SH3 domain has been a model system for ag...

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Detalles Bibliográficos
Autores principales: Gardon, Luis, Becker, Nina, Rähse, Nick, Hölbling, Christoph, Apostolidis, Athina, Schulz, Celina M., Bochinsky, Kevin, Gremer, Lothar, Heise, Henrike, Lakomek, Nils-Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691488/
https://www.ncbi.nlm.nih.gov/pubmed/38046811
http://dx.doi.org/10.3389/fmolb.2023.1254721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691488/
https://www.ncbi.nlm.nih.gov/pubmed/38046811
http://dx.doi.org/10.3389/fmolb.2023.1254721

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