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Infernape uncovers cell type–specific and spatially resolved alternative polyadenylation in the brain

Differential polyadenylation sites (PAs) critically regulate gene expression, but their cell type–specific usage and spatial distribution in the brain have not been systematically characterized. Here, we present Infernape, which infers and quantifies PA usage from single-cell and spatial transcripto...

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Detalles Bibliográficos
Autores principales: Kang, Bowei, Yang, Yalan, Hu, Kaining, Ruan, Xiangbin, Liu, Yi-Lin, Lee, Pinky, Lee, Jasper, Wang, Jingshu, Zhang, Xiaochang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691540/
https://www.ncbi.nlm.nih.gov/pubmed/37907328
http://dx.doi.org/10.1101/gr.277864.123