A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex

Human cytomegalovirus (HCMV) is an important pathogen for which new antiviral drugs are needed. HCMV, like other herpesviruses, encodes a nuclear egress complex (NEC) composed of two subunits, UL50 and UL53, whose interaction is crucial for viral replication. To explore whether small molecules can e...

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Detalles Bibliográficos
Autores principales: Chen, Han, Lye, Ming F., Gorgulla, Christoph, Ficarro, Scott B., Cuny, Gregory D., Scott, David A., Wu, Fan, Rothlauf, Paul W., Wang, Xiaoou, Fernandez, Rosio, Pesola, Jean M., Draga, Sorin, Marto, Jarrod A., Hogle, James M., Arthanari, Haribabu, Coen, Donald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691697/
https://www.ncbi.nlm.nih.gov/pubmed/37976321
http://dx.doi.org/10.1371/journal.ppat.1011781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691697/
https://www.ncbi.nlm.nih.gov/pubmed/37976321
http://dx.doi.org/10.1371/journal.ppat.1011781

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