Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression

We previously reported that macrolide antibiotics, such as clarithromycin (CAM), blocked autophagy flux, and simultaneous proteasome and autophagy inhibition by bortezomib (BTZ) plus CAM resulted in enhanced apoptosis induction in multiple myeloma (MM) cells via increased endoplasmic reticulum (ER)...

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Detalles Bibliográficos
Autores principales: Moriya, Shota, Kazama, Hiromi, Hino, Hirotsugu, Takano, Naoharu, Hiramoto, Masaki, Aizawa, Shin, Miyazawa, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691716/
https://www.ncbi.nlm.nih.gov/pubmed/38039297
http://dx.doi.org/10.1371/journal.pone.0295273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691716/
https://www.ncbi.nlm.nih.gov/pubmed/38039297
http://dx.doi.org/10.1371/journal.pone.0295273

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