Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR

To study and then harness the tumor-specific T cell dynamics after allogeneic hematopoietic stem cell transplant, we typed the frequency, phenotype, and function of lymphocytes directed against tumor-associated antigens (TAAs) in 39 consecutive transplanted patients, for 1 year after transplant. We...

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Detalles Bibliográficos
Autores principales: Manfredi, Francesco, Stasi, Lorena, Buonanno, Silvia, Marzuttini, Francesca, Noviello, Maddalena, Mastaglio, Sara, Abbati, Danilo, Potenza, Alessia, Balestrieri, Chiara, Cianciotti, Beatrice Claudia, Tassi, Elena, Feola, Sara, Toffalori, Cristina, Punta, Marco, Magnani, Zulma, Camisa, Barbara, Tiziano, Elena, Lupo-Stanghellini, Maria Teresa, Branca, Rui Mamede, Lehtiö, Janne, Sikanen, Tiina M., Haapala, Markus J., Cerullo, Vincenzo, Casucci, Monica, Vago, Luca, Ciceri, Fabio, Bonini, Chiara, Ruggiero, Eliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691777/
https://www.ncbi.nlm.nih.gov/pubmed/38039364
http://dx.doi.org/10.1126/sciadv.adg8014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691777/
https://www.ncbi.nlm.nih.gov/pubmed/38039364
http://dx.doi.org/10.1126/sciadv.adg8014

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