Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

The canonical target of the glucagon-like peptide-1 receptor (GLP-1R), Protein Kinase A (PKA), has been shown to stimulate mechanistic Target of Rapamycin Complex 1 (mTORC1) by phosphorylating the mTOR-regulating protein Raptor at Ser(791) following β-adrenergic stimulation. The objective of these s...

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Detalles Bibliográficos
Autores principales: Le, Thao DV, Liu, Dianxin, Besing, Gai-Linn K, Raghavan, Ritika, Ellis, Blair J, Ceddia, Ryan P, Collins, Sheila, Ayala, Julio E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
https://www.ncbi.nlm.nih.gov/pubmed/37930356
http://dx.doi.org/10.7554/eLife.80944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
https://www.ncbi.nlm.nih.gov/pubmed/37930356
http://dx.doi.org/10.7554/eLife.80944

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