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Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
The canonical target of the glucagon-like peptide-1 receptor (GLP-1R), Protein Kinase A (PKA), has been shown to stimulate mechanistic Target of Rapamycin Complex 1 (mTORC1) by phosphorylating the mTOR-regulating protein Raptor at Ser(791) following β-adrenergic stimulation. The objective of these s...
Autores principales: | Le, Thao DV, Liu, Dianxin, Besing, Gai-Linn K, Raghavan, Ritika, Ellis, Blair J, Ceddia, Ryan P, Collins, Sheila, Ayala, Julio E |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691799/ https://www.ncbi.nlm.nih.gov/pubmed/37930356 http://dx.doi.org/10.7554/eLife.80944 |
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