Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

INTRODUCTION: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer. We describe the generation and selection of a potent antagonistic C5aR...

Descripción completa

Detalles Bibliográficos
Autores principales: Cyranka, Leon, Mariegaard, Ida, Skjødt, Mikkel-Ole, Bayarri-Olmos, Rafael, Mollnes, Tom Eirik, Garred, Peter, Rosbjerg, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691831/
https://www.ncbi.nlm.nih.gov/pubmed/37952515
http://dx.doi.org/10.1159/000535084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691831/
https://www.ncbi.nlm.nih.gov/pubmed/37952515
http://dx.doi.org/10.1159/000535084

Ejemplares similares