Cargando…

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

INTRODUCTION: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer. We describe the generation and selection of a potent antagonistic C5aR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cyranka, Leon, Mariegaard, Ida, Skjødt, Mikkel-Ole, Bayarri-Olmos, Rafael, Mollnes, Tom Eirik, Garred, Peter, Rosbjerg, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	S. Karger AG 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691831/ https://www.ncbi.nlm.nih.gov/pubmed/37952515 http://dx.doi.org/10.1159/000535084

Ejemplares similares

SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven Inflammation
por: Jarlhelt, Ida, et al.
Publicado: (2021)

Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
por: Götz, Maximilian Peter, et al.
Publicado: (2022)

The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

Reply to Lassaunière: On the functional characterization of the Y453F RBD variant found in cluster 5 SARS-CoV-2
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2018)

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus
por: Rosbjerg, Anne, et al.
Publicado: (2016)

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities
por: Hertz, Cecilie E., et al.
Publicado: (2018)

Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway
por: Rosbjerg, Anne, et al.
Publicado: (2017)

Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
por: Garred, Peter, et al.
Publicado: (2021)

C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques
por: Pilely, Katrine, et al.
Publicado: (2017)

The alternative complement pathway revisited
por: Harboe, Morten, et al.
Publicado: (2008)

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

The Lectin Complement Pathway Is Involved in Protection Against Enteroaggregative Escherichia coli Infection
por: Adler Sørensen, Camilla, et al.
Publicado: (2018)

Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG
por: Larsen, Mads Delbo, et al.
Publicado: (2019)

Editorial: The Role of Complement in Health and Disease
por: Cedzyński, Maciej, et al.
Publicado: (2019)

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement
por: Zhang, Jie, et al.
Publicado: (2020)

Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines
por: Kellnerová, Sára, et al.
Publicado: (2020)

Functional Analysis of Ficolin-3 Mediated Complement Activation
por: Hein, Estrid, et al.
Publicado: (2010)

Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

Complement Activation in 22q11.2 Deletion Syndrome
por: Grinde, Dina, et al.
Publicado: (2020)

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
por: Landsem, Anne, et al.
Publicado: (2022)

In vivo inhibition of the antibody response by a complement receptor- specific monoclonal antibody
Publicado: (1990)

Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo
por: Genster, Ninette, et al.
Publicado: (2017)

Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene
por: Emblem, Åse, et al.
Publicado: (2022)

Short-Lived Antibody-Mediated Saliva Immunity against SARS-CoV-2 after Vaccination
por: Madsen, Johannes Roth, et al.
Publicado: (2023)

The Role of Complement in Liver Injury, Regeneration, and Transplantation
por: Thorgersen, Ebbe Billmann, et al.
Publicado: (2019)

Genetic Variation of COLEC10 and COLEC11 and Association with Serum Levels of Collectin Liver 1 (CL-L1) and Collectin Kidney 1 (CL-K1)
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2015)

CD14 and Complement Crosstalk and Largely Mediate the Transcriptional Response to Escherichia coli in Human Whole Blood as Revealed by DNA Microarray
por: Lau, Corinna, et al.
Publicado: (2015)

A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis
por: Sikkeland, Liv I. B., et al.
Publicado: (2023)

Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5 emerge together with CD14 as promising targets
por: Barratt-Due, Andreas, et al.
Publicado: (2017)

Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases
por: Shields, Kelly J., et al.
Publicado: (2017)

Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
por: Lau, Corinna, et al.
Publicado: (2015)

Distinguishing SARS-CoV-2 infection and vaccine responses up to 18 months post-infection using nucleocapsid protein and receptor-binding domain antibodies
por: Jarlhelt, Ida, et al.
Publicado: (2023)

Complement-dependent cytotoxicity of anti-human osteogenic sarcoma monoclonal antibodies.
por: Price, M. R., et al.
Publicado: (1982)

Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer
por: Meyer, Saskia, et al.
Publicado: (2014)

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody
por: Gulati, Sunita, et al.
Publicado: (2019)

High mobility group box-1 protein – one step closer to the clinic?
por: Mollnes, Tom Eirik
Publicado: (2008)

Pentraxins in Complement Activation and Regulation
por: Ma, Ying Jie, et al.
Publicado: (2018)

Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies
por: Davies, Terry F., et al.
Publicado: (2022)

Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study
por: Hokstad, Ingrid, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_mvi8l6l5irlk2f31sgemn2njcu