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Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

INTRODUCTION: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer. We describe the generation and selection of a potent antagonistic C5aR...

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Detalles Bibliográficos
Autores principales:	Cyranka, Leon, Mariegaard, Ida, Skjødt, Mikkel-Ole, Bayarri-Olmos, Rafael, Mollnes, Tom Eirik, Garred, Peter, Rosbjerg, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	S. Karger AG 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691831/ https://www.ncbi.nlm.nih.gov/pubmed/37952515 http://dx.doi.org/10.1159/000535084

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