Cargando…

The role of antidrug antibodies in ustekinumab therapy and the impact of methotrexate

OBJECTIVE: We investigated the impact of concomitant MTX on ustekinumab (UST) levels and antidrug antibody (ADA) formation in PsA and evaluated consequences in pharmacodynamics and pharmacokinetics. METHODS: We conducted a post-hoc analysis on 112 PsA serum samples of subjects treated with open-labe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mojtahed Poor, Sorwe, Henke, Marina, Ulshöfer, Thomas, Köhm, Michaela, Behrens, Frank, Burkhardt, Harald, Schiffmann, Susanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691926/ https://www.ncbi.nlm.nih.gov/pubmed/37079726 http://dx.doi.org/10.1093/rheumatology/kead177

Ejemplares similares

Innovative Imaging Technique for Visualization of Vascularization and Established Methods for Detection of Musculoskeletal Inflammation in Psoriasis Patients
por: Köhm, Michaela, et al.
Publicado: (2020)

Response to Biologic Drugs in Patients With Rheumatoid Arthritis and Antidrug Antibodies
por: Bitoun, Samuel, et al.
Publicado: (2023)

Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor
por: Arai, Takahiro, et al.
Publicado: (2022)

Increased Induction Infliximab Clearance Predicts Early Antidrug Antibody Detection
por: Eser, Alexander, et al.
Publicado: (2020)

Sodium Bituminosulfonate Used to Treat Rosacea Modulates Generation of Inflammatory Mediators by Primary Human Neutrophils
por: Schiffmann, Susanne, et al.
Publicado: (2021)

Therapeutic Protein PEPylation: The Helix of Nonfouling Synthetic Polypeptides Minimizes Antidrug Antibody Generation
por: Hou, Yingqin, et al.
Publicado: (2019)

Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis
por: Behrens, Frank, et al.
Publicado: (2016)

Impact of glycoengineering and antidrug antibodies on the anticancer activity of a plant‐made lectin‐Fc fusion protein
por: Dent, Matthew, et al.
Publicado: (2022)

Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups
por: Assmann, Gunter, et al.
Publicado: (2020)

Correlation between HLA haplotypes and the development of antidrug antibodies in a cohort of patients with rheumatic diseases
por: Benucci, Maurizio, et al.
Publicado: (2018)

The Pharmacological Potential of Novel Melittin Variants from the Honeybee and Solitary Bees against Inflammation and Cancer
por: Erkoc, Pelin, et al.
Publicado: (2022)

The immunomodulatory potential of the arylmethylaminosteroid sc1o
por: Blum, Leonard, et al.
Publicado: (2020)

Pharmacokinetic Effects of Antidrug Antibodies Occurring in Healthy Subjects After a Single Dose of Intravenous Infliximab
por: Ehrenpreis, Eli D.
Publicado: (2017)

Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision
por: Adair, Patrick R., et al.
Publicado: (2017)

Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove
por: Tsakok, Teresa, et al.
Publicado: (2023)

Association of High Levels of Antidrug Antibodies Against Atezolizumab With Clinical Outcomes and T-Cell Responses in Patients With Hepatocellular Carcinoma
por: Kim, Chan, et al.
Publicado: (2022)

A machine learning approach for identifying variables associated with risk of developing neutralizing antidrug antibodies to factor VIII
por: Rawal, Atul, et al.
Publicado: (2023)

Comparing the Effects of Rocaglates on Energy Metabolism and Immune Modulation on Cells of the Human Immune System
por: Schiffmann, Susanne, et al.
Publicado: (2023)

A mechanistic pharmacokinetic model with drug and antidrug antibody interplay, and its application for assessing the impact of immunogenicity response on bioequivalence testing
por: Liao, Kai H., et al.
Publicado: (2020)

Antidrug antibodies against TNF-blocking agents: correlations between disease activity, hypersensitivity reactions, and different classes of immunoglobulins
por: Benucci, Maurizio, et al.
Publicado: (2015)

Allelic variation in HLA‐DRB1 is associated with development of antidrug antibodies in cancer patients treated with atezolizumab that are neutralizing in vitro
por: Hammer, Christian, et al.
Publicado: (2022)

Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic
por: Kumar, Manish, et al.
Publicado: (2021)

Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach
por: Ingelfinger, Rebecca, et al.
Publicado: (2020)

Antidrug antibody formation during tumor necrosis factor α inhibitor treatment of severe psoriatic patients in the real-life practice
por: Herszényi, Krisztina, et al.
Publicado: (2019)

Neutralizing antidrug antibody to emicizumab in patients with severe hemophilia A: Case report of a first noninhibitor patient and review of the literature
por: Kizilocak, Hande, et al.
Publicado: (2023)

Human Cytomegalovirus Infection Increases Both Antibody- and Non–Antibody-Dependent Cellular Reactivity by Natural Killer Cells
por: Michelo, Clive M., et al.
Publicado: (2017)

Does concomitant methotrexate confer clinical benefits in patients treated with prior biologic therapy? Analysis of data from a noninterventional study of rheumatoid arthritis patients initiating treatment with adalimumab
por: Schmalzing, Marc, et al.
Publicado: (2020)

Characterization of ACE Inhibitors and AT(1)R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model
por: Reus, Philipp, et al.
Publicado: (2021)

79664 Complement Driven Auto-Reactive Antibodies in Lung Transplantation
por: McQuiston, Alexander, et al.
Publicado: (2021)

Late Reaction to Ustekinumab Infusion
por: Morais, Marina Resener, et al.
Publicado: (2013)

Adalimumab serum levels and antidrug antibodies towards adalimumab in peripheral spondyloarthritis: no association with clinical response to treatment or with disease relapse upon treatment discontinuation
por: Paramarta, Jacqueline E, et al.
Publicado: (2014)

Evaluation of the Cross-reactivity of Antidrug Antibodies to CT-P13 and Infliximab Reference Product (Remicade): An Analysis Using Immunoassays Tagged with Both Agents
por: Reinisch, Walter, et al.
Publicado: (2017)

Minimal disease activity is a stable measure of therapeutic response in psoriatic arthritis patients receiving treatment with adalimumab
por: Behrens, Frank, et al.
Publicado: (2018)

Anti-RNA polymerase III antibodies in patients with systemic sclerosis detected by indirect immunofluorescence and ELISA
por: Parker, J. C., et al.
Publicado: (2008)

Development of a novel magnetic particle-based agglutination immunoassay for anticardiolipin antibody detection in syphilis
por: Shukla, Mayur R, et al.
Publicado: (2020)

38227 Specific and highly potent human monoclonal antibodies against SARS-CoV-2
por: de Mattos Barbosa, Mayara Garcia, et al.
Publicado: (2021)

No deleterious effect of low dose methotrexate on titanium implant osseointegration in a rabbit model
por: Carvas, Janaina Badin, et al.
Publicado: (2011)

The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development
por: Zhang, Yu, et al.
Publicado: (2013)

Antithymocyte Globulin Antibody Titer Congruent With Kidney Transplantation: Analysis of Incidence, Outcomes, Cost, and Alternative Targets
por: Lattimore, Sherene, et al.
Publicado: (2019)

Distinct antibody profiles in HLA-B(∗)57(+), HLA-B(∗)57(−) HIV controllers and chronic progressors
por: Klingler, Jéromine, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_iee73mbvm0p7ptl7505ficldmf