Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394

Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of patients with metastatic cSCC is poor emphasizing the need for new therapies. We have previously reported that the activation of Ras/MEK/ERK1/2 and transforming growth factor β (TGF-β)/Smad2 signalin...

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Detalles Bibliográficos
Autores principales: Siljamäki, Elina, Riihilä, Pilvi, Suwal, Ujjwal, Nissinen, Liisa, Rappu, Pekka, Kallajoki, Markku, Kähäri, Veli-Matti, Heino, Jyrki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691969/
https://www.ncbi.nlm.nih.gov/pubmed/37864034
http://dx.doi.org/10.1038/s41388-023-02863-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691969/
https://www.ncbi.nlm.nih.gov/pubmed/37864034
http://dx.doi.org/10.1038/s41388-023-02863-8

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