Mitochondrial E3 ligase MARCH5 is a safeguard against DNA-PKcs-mediated immune signaling in mitochondria-damaged cells

Mitochondrial dysfunction is important in various chronic degenerative disorders, and aberrant immune responses elicited by cytoplasmic mitochondrial DNA (mtDNA) may be related. Here, we developed mtDNA-targeted MTERF1-FokI and TFAM-FokI endonuclease systems to induce mitochondrial DNA double-strand...

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Detalles Bibliográficos
Autores principales: Heo, June, Park, Yeon-Ji, Kim, Yonghyeon, Lee, Ho-Soo, Kim, Jeongah, Kwon, Soon-Hwan, Kang, Myeong-Gyun, Rhee, Hyun-Woo, Sun, Woong, Lee, Jae-Ho, Cho, Hyeseong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692114/
https://www.ncbi.nlm.nih.gov/pubmed/38040710
http://dx.doi.org/10.1038/s41419-023-06315-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692114/
https://www.ncbi.nlm.nih.gov/pubmed/38040710
http://dx.doi.org/10.1038/s41419-023-06315-9

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