Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents. These structures correspond to free forms and complexes with activators, substrates, and inhibitors. Here we report the conformation of an oxi...

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Detalles Bibliográficos
Autores principales: Pous, Joan, Baginski, Blazej, Martin-Malpartida, Pau, González, Lorena, Scarpa, Margherita, Aragon, Eric, Ruiz, Lidia, Mees, Rebeca A., Iglesias-Fernández, Javier, Orozco, Modesto, Nebreda, Angel R., Macias, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692146/
https://www.ncbi.nlm.nih.gov/pubmed/38040726
http://dx.doi.org/10.1038/s41467-023-43763-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692146/
https://www.ncbi.nlm.nih.gov/pubmed/38040726
http://dx.doi.org/10.1038/s41467-023-43763-5

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