Accurate and efficient estimation of local heritability using summary statistics and the linkage disequilibrium matrix

Existing SNP-heritability estimators that leverage summary statistics from genome-wide association studies (GWAS) are much less efficient (i.e., have larger standard errors) than the restricted maximum likelihood (REML) estimators which require access to individual-level data. We introduce a new met...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Hui, Mazumder, Rahul, Lin, Xihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692177/
https://www.ncbi.nlm.nih.gov/pubmed/38040712
http://dx.doi.org/10.1038/s41467-023-43565-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692177/
https://www.ncbi.nlm.nih.gov/pubmed/38040712
http://dx.doi.org/10.1038/s41467-023-43565-9

Ejemplares similares