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Accurate and efficient estimation of local heritability using summary statistics and the linkage disequilibrium matrix
Existing SNP-heritability estimators that leverage summary statistics from genome-wide association studies (GWAS) are much less efficient (i.e., have larger standard errors) than the restricted maximum likelihood (REML) estimators which require access to individual-level data. We introduce a new met...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692177/ https://www.ncbi.nlm.nih.gov/pubmed/38040712 http://dx.doi.org/10.1038/s41467-023-43565-9 |