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Serum metabolome and liver transcriptome reveal acrolein inhalation-induced sex-specific homeostatic dysfunction

Acrolein, a respiratory irritant, induces systemic neuroendocrine stress. However, peripheral metabolic effects have not been examined. Male and female WKY rats were exposed to air (0 ppm) or acrolein (3.16 ppm) for 4 h, followed by immediate serum and liver tissue collection. Serum metabolomics in...

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Detalles Bibliográficos
Autores principales: Alewel, Devin I., Rentschler, Katherine M., Jackson, Thomas W., Schladweiler, Mette C., Astriab-Fisher, Anna, Evansky, Paul A., Kodavanti, Urmila P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692194/
https://www.ncbi.nlm.nih.gov/pubmed/38040807
http://dx.doi.org/10.1038/s41598-023-48413-w