Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity

Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we show that lipotoxicity increased histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDA...

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Detalles Bibliográficos
Autores principales: Martin, Sheree D., Connor, Timothy, Sanigorski, Andrew, McEwen, Kevin A., Henstridge, Darren C., Nijagal, Brunda, De Souza, David, Tull, Dedreia L., Meikle, Peter J., Kowalski, Greg M., Bruce, Clinton R., Gregorevic, Paul, Febbraio, Mark A., Collier, Fiona M., Walder, Ken R., McGee, Sean L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692215/
https://www.ncbi.nlm.nih.gov/pubmed/38040704
http://dx.doi.org/10.1038/s41419-023-06319-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692215/
https://www.ncbi.nlm.nih.gov/pubmed/38040704
http://dx.doi.org/10.1038/s41419-023-06319-5

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