Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility

Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66 (SI = 2019.80, S = 1.9 μg/mL), a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility were identified by replacement of the biphenyl moie...

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Detalles Bibliográficos
Autores principales: Zhao, Li-Min, Pannecouque, Christophe, Clercq, Erik De, Wang, Shuai, Chen, Fen-Er
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692386/
https://www.ncbi.nlm.nih.gov/pubmed/38045058
http://dx.doi.org/10.1016/j.apsb.2023.07.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692386/
https://www.ncbi.nlm.nih.gov/pubmed/38045058
http://dx.doi.org/10.1016/j.apsb.2023.07.008

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