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Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases

Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs and subsequently ubiquitinate them via the RING domain, ther...

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Detalles Bibliográficos
Autores principales: Han, Jinhua, Mu, Yanhua, Huang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692494/
https://www.ncbi.nlm.nih.gov/pubmed/38047137
http://dx.doi.org/10.1016/j.cellin.2023.100128
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author Han, Jinhua
Mu, Yanhua
Huang, Jun
author_facet Han, Jinhua
Mu, Yanhua
Huang, Jun
author_sort Han, Jinhua
collection PubMed
description Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs and subsequently ubiquitinate them via the RING domain, thereby bridging the SUMO and ubiquitin signaling pathways. STUbLs participate in a wide array of molecular processes, including cell cycle regulation, DNA repair, replication, and mitosis, operating under both normal conditions and in response to challenges such as genotoxic stress. Their ability to catalyze various types of ubiquitin chains results in diverse proteolytic and non-proteolytic outcomes for target substrates. Importantly, STUbLs are strategically positioned in close proximity to SUMO proteases and deubiquitinases (DUBs), ensuring precise and dynamic control over their target proteins. In this review, we provide insights into the unique properties and indispensable roles of STUbLs, with a particular emphasis on their significance in preserving genome integrity in humans.
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spelling pubmed-106924942023-12-03 Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases Han, Jinhua Mu, Yanhua Huang, Jun Cell Insight Review Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs and subsequently ubiquitinate them via the RING domain, thereby bridging the SUMO and ubiquitin signaling pathways. STUbLs participate in a wide array of molecular processes, including cell cycle regulation, DNA repair, replication, and mitosis, operating under both normal conditions and in response to challenges such as genotoxic stress. Their ability to catalyze various types of ubiquitin chains results in diverse proteolytic and non-proteolytic outcomes for target substrates. Importantly, STUbLs are strategically positioned in close proximity to SUMO proteases and deubiquitinases (DUBs), ensuring precise and dynamic control over their target proteins. In this review, we provide insights into the unique properties and indispensable roles of STUbLs, with a particular emphasis on their significance in preserving genome integrity in humans. Elsevier 2023-10-23 /pmc/articles/PMC10692494/ /pubmed/38047137 http://dx.doi.org/10.1016/j.cellin.2023.100128 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Han, Jinhua
Mu, Yanhua
Huang, Jun
Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
title Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
title_full Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
title_fullStr Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
title_full_unstemmed Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
title_short Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
title_sort preserving genome integrity: the vital role of sumo-targeted ubiquitin ligases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692494/
https://www.ncbi.nlm.nih.gov/pubmed/38047137
http://dx.doi.org/10.1016/j.cellin.2023.100128
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