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Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs and subsequently ubiquitinate them via the RING domain, ther...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692494/ https://www.ncbi.nlm.nih.gov/pubmed/38047137 http://dx.doi.org/10.1016/j.cellin.2023.100128 |
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author | Han, Jinhua Mu, Yanhua Huang, Jun |
author_facet | Han, Jinhua Mu, Yanhua Huang, Jun |
author_sort | Han, Jinhua |
collection | PubMed |
description | Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs and subsequently ubiquitinate them via the RING domain, thereby bridging the SUMO and ubiquitin signaling pathways. STUbLs participate in a wide array of molecular processes, including cell cycle regulation, DNA repair, replication, and mitosis, operating under both normal conditions and in response to challenges such as genotoxic stress. Their ability to catalyze various types of ubiquitin chains results in diverse proteolytic and non-proteolytic outcomes for target substrates. Importantly, STUbLs are strategically positioned in close proximity to SUMO proteases and deubiquitinases (DUBs), ensuring precise and dynamic control over their target proteins. In this review, we provide insights into the unique properties and indispensable roles of STUbLs, with a particular emphasis on their significance in preserving genome integrity in humans. |
format | Online Article Text |
id | pubmed-10692494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106924942023-12-03 Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases Han, Jinhua Mu, Yanhua Huang, Jun Cell Insight Review Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs and subsequently ubiquitinate them via the RING domain, thereby bridging the SUMO and ubiquitin signaling pathways. STUbLs participate in a wide array of molecular processes, including cell cycle regulation, DNA repair, replication, and mitosis, operating under both normal conditions and in response to challenges such as genotoxic stress. Their ability to catalyze various types of ubiquitin chains results in diverse proteolytic and non-proteolytic outcomes for target substrates. Importantly, STUbLs are strategically positioned in close proximity to SUMO proteases and deubiquitinases (DUBs), ensuring precise and dynamic control over their target proteins. In this review, we provide insights into the unique properties and indispensable roles of STUbLs, with a particular emphasis on their significance in preserving genome integrity in humans. Elsevier 2023-10-23 /pmc/articles/PMC10692494/ /pubmed/38047137 http://dx.doi.org/10.1016/j.cellin.2023.100128 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Han, Jinhua Mu, Yanhua Huang, Jun Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases |
title | Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases |
title_full | Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases |
title_fullStr | Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases |
title_full_unstemmed | Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases |
title_short | Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases |
title_sort | preserving genome integrity: the vital role of sumo-targeted ubiquitin ligases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692494/ https://www.ncbi.nlm.nih.gov/pubmed/38047137 http://dx.doi.org/10.1016/j.cellin.2023.100128 |
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