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Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation

Reducing inflammation by diet is a major goal for prevention or lowering symptoms of a variety of diseases, such as auto-immune reactions and cancers. Natural polysaccharides are increasingly gaining attention due to their potential immunomodulating capacity. Structures of those molecules are highly...

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Detalles Bibliográficos
Autores principales: Pedrosa, Lucas de Freitas, de Vos, Paul, Fabi, João Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692654/
https://www.ncbi.nlm.nih.gov/pubmed/38046895
http://dx.doi.org/10.1016/j.crstbi.2023.100112
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author Pedrosa, Lucas de Freitas
de Vos, Paul
Fabi, João Paulo
author_facet Pedrosa, Lucas de Freitas
de Vos, Paul
Fabi, João Paulo
author_sort Pedrosa, Lucas de Freitas
collection PubMed
description Reducing inflammation by diet is a major goal for prevention or lowering symptoms of a variety of diseases, such as auto-immune reactions and cancers. Natural polysaccharides are increasingly gaining attention due to their potential immunomodulating capacity. Structures of those molecules are highly important for their effects on the innate immune system, cytokine production and secretion, and enzymes in immune cells. Such polysaccharides include β-glucans, pectins, fucoidans, and fructans. To better understand the potential of these immunomodulatory molecules, it is crucial to enhance dedicated research in the area. A bibliometric analysis was performed to set a starting observation point. Major pillars of inflammation, such as pattern recognition receptors (PRRs), enzymatic production of inflammatory molecules, and involvement in specific pathways such as Nuclear-factor kappa-B (NF-kB), involved in cell transcription, survival, and cytokine production, and mitogen-activated protein kinase (MAPK), a regulator of genetic expression, mitosis, and cell differentiation. Therefore, the outcomes from polysaccharide applications in those scenarios are discussed.
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spelling pubmed-106926542023-12-03 Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation Pedrosa, Lucas de Freitas de Vos, Paul Fabi, João Paulo Curr Res Struct Biol Review Article Reducing inflammation by diet is a major goal for prevention or lowering symptoms of a variety of diseases, such as auto-immune reactions and cancers. Natural polysaccharides are increasingly gaining attention due to their potential immunomodulating capacity. Structures of those molecules are highly important for their effects on the innate immune system, cytokine production and secretion, and enzymes in immune cells. Such polysaccharides include β-glucans, pectins, fucoidans, and fructans. To better understand the potential of these immunomodulatory molecules, it is crucial to enhance dedicated research in the area. A bibliometric analysis was performed to set a starting observation point. Major pillars of inflammation, such as pattern recognition receptors (PRRs), enzymatic production of inflammatory molecules, and involvement in specific pathways such as Nuclear-factor kappa-B (NF-kB), involved in cell transcription, survival, and cytokine production, and mitogen-activated protein kinase (MAPK), a regulator of genetic expression, mitosis, and cell differentiation. Therefore, the outcomes from polysaccharide applications in those scenarios are discussed. Elsevier 2023-11-11 /pmc/articles/PMC10692654/ /pubmed/38046895 http://dx.doi.org/10.1016/j.crstbi.2023.100112 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Pedrosa, Lucas de Freitas
de Vos, Paul
Fabi, João Paulo
Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation
title Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation
title_full Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation
title_fullStr Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation
title_full_unstemmed Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation
title_short Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation
title_sort nature's soothing solution: harnessing the potential of food-derived polysaccharides to control inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692654/
https://www.ncbi.nlm.nih.gov/pubmed/38046895
http://dx.doi.org/10.1016/j.crstbi.2023.100112
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