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Tissue factor targeting peptide enhances nanoparticle binding and delivery of a synthetic specialized pro-resolving lipid mediator to injured arteries

BACKGROUND: Specialized pro-resolving lipid mediators (SPM) such as resolvin D1 (RvD1) attenuate inflammation and exhibit vasculo-protective properties. METHODS: We investigated poly-lactic-co-glycolic acid (PLGA)-based nanoparticles (NP), containing a peptide targeted to tissue factor (TF) for deli...

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Detalles Bibliográficos
Autores principales: Levy, Elizabeth S., Kim, Alexander S., Werlin, Evan, Chen, Mian, Sansbury, Brian E., Spite, Matthew, Desai, Tejal A., Conte, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692706/
https://www.ncbi.nlm.nih.gov/pubmed/38045567
http://dx.doi.org/10.1016/j.jvssci.2023.100126