Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease

Proteomic studies have identified moesin (MSN), a protein containing a four-point-one, ezrin, radixin, moesin (FERM) domain, and the receptor CD44 as hub proteins found within a coexpression module strongly linked to Alzheimer’s disease (AD) traits and microglia. These proteins are more abundant in...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692723/
https://www.ncbi.nlm.nih.gov/pubmed/37866628
http://dx.doi.org/10.1016/j.jbc.2023.105382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692723/
https://www.ncbi.nlm.nih.gov/pubmed/37866628
http://dx.doi.org/10.1016/j.jbc.2023.105382

Ejemplares similares