Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring

Non-alcoholic fatty liver disease (NAFLD) is the most pervasive liver pathology worldwide. Here, we demonstrate that the ubiquitin E3 ligase Huwe1 is vital in NAFLD pathogenesis. Using mass spectrometry and RNA sequencing, we reveal that liver-specific deletion of Huwe1 (Huwe1(LKO)) in 1-year-old mi...

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Detalles Bibliográficos
Autores principales: Feng, William W., Bang, Scott, Takacs, Eric M., Day, Cora, Crawford, Katherine J., Al-Sheyab, Ruba, Almufarrej, Dara B., Wells, Wendy, Ilchenko, Serguei, Kasumov, Takhar, Kon, Ning, Novak, Colleen M., Gu, Wei, Kurokawa, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692727/
https://www.ncbi.nlm.nih.gov/pubmed/38047073
http://dx.doi.org/10.1016/j.isci.2023.108405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692727/
https://www.ncbi.nlm.nih.gov/pubmed/38047073
http://dx.doi.org/10.1016/j.isci.2023.108405

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