Atypical genotoxicity of carcinogenic nickel(II): Linkage to dNTP biosynthesis, DNA-incorporated rNMPs, and impaired repair of TOP1-DNA crosslinks

Cancer is a genetic disease requiring multiple mutations for its development. However, many carcinogens are DNA-unreactive and nonmutagenic and consequently described as nongenotoxic. One of such carcinogens is nickel, a global environmental pollutant abundantly emitted by burning of coal. We invest...

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Detalles Bibliográficos
Autores principales: Krawic, Casey, Luczak, Michal W., Valiente, Sophia, Zhitkovich, Anatoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692736/
https://www.ncbi.nlm.nih.gov/pubmed/37890780
http://dx.doi.org/10.1016/j.jbc.2023.105385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692736/
https://www.ncbi.nlm.nih.gov/pubmed/37890780
http://dx.doi.org/10.1016/j.jbc.2023.105385

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