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Atypical genotoxicity of carcinogenic nickel(II): Linkage to dNTP biosynthesis, DNA-incorporated rNMPs, and impaired repair of TOP1-DNA crosslinks

Cancer is a genetic disease requiring multiple mutations for its development. However, many carcinogens are DNA-unreactive and nonmutagenic and consequently described as nongenotoxic. One of such carcinogens is nickel, a global environmental pollutant abundantly emitted by burning of coal. We invest...

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Detalles Bibliográficos
Autores principales:	Krawic, Casey, Luczak, Michal W., Valiente, Sophia, Zhitkovich, Anatoly
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692736/ https://www.ncbi.nlm.nih.gov/pubmed/37890780 http://dx.doi.org/10.1016/j.jbc.2023.105385

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