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Targeting SIRT1 synergistically improves the antitumor effect of JQ-1 in hepatocellular carcinoma

Bromodomain and extraterminal domain protein inhibitors have shown therapeutic promise in hepatocellular carcinoma. However, resistance to bromodomain and extraterminal domain protein inhibitors has emerged in preclinical trials, presenting an immense clinical challenge, and the mechanisms are uncle...

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Detalles Bibliográficos
Autores principales: Jiang, Yuancong, Miao, Xiaolong, Wu, Zelai, Xie, Weixun, Wang, Li, Liu, Han, Gong, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692793/
https://www.ncbi.nlm.nih.gov/pubmed/38045194
http://dx.doi.org/10.1016/j.heliyon.2023.e22093