Cell aggregation activates small GTPase Rac1 and induces CD44 cleavage by maintaining lipid raft integrity

Lipid rafts are highly ordered membrane domains that are enriched in cholesterol and glycosphingolipids and serve as major platforms for signal transduction. Cell detachment from the extracellular matrix (ECM) triggers lipid raft disruption and anoikis, which is a barrier for cancer cells to metasta...

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Detalles Bibliográficos
Autores principales: Li, Dong, Park, Younhee, Hemati, Hami, Liu, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692920/
https://www.ncbi.nlm.nih.gov/pubmed/37866630
http://dx.doi.org/10.1016/j.jbc.2023.105377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692920/
https://www.ncbi.nlm.nih.gov/pubmed/37866630
http://dx.doi.org/10.1016/j.jbc.2023.105377

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