Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis

BACKGROUND: Hedgehog-Gli1 signaling induces development of two common neurological features seen in pancreatic ductal adenocarcinoma (PDAC): peripheral neural invasion (PNI) and peripheral neural remodeling (PNR). However, the underlying molecular mechanisms in cancer cells and nerves within Gli1-de...

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Detalles Bibliográficos
Autores principales: Dai, Weiqi, Wu, Xiaoli, Li, Jingjing, Tang, Wenxi, Wang, Ying, Xu, Wenqiang, Han, Dengyu, Xu, Xiaorong, Xu, Xuanfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693175/
https://www.ncbi.nlm.nih.gov/pubmed/38041128
http://dx.doi.org/10.1186/s13046-023-02894-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693175/
https://www.ncbi.nlm.nih.gov/pubmed/38041128
http://dx.doi.org/10.1186/s13046-023-02894-9

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