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Niraparib restrains prostate cancer cell proliferation and metastasis and tumor growth in mice by regulating the lncRNA MEG3/miR-181-5p/GATA6 pathway
BACKGROUND: Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), have gained approval for treating patients with castration-resistant prostate cancer (CRPC). Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), plays a role in inhibiting tumorigenesis through regulating DNA repair...
Autores principales: | Cheng, Ji, Sun, Yi, Zhao, Huacai, Ren, Wei, Gao, Dan, Wang, Zhigang, Lv, Wei, Dong, Qingchuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693232/ https://www.ncbi.nlm.nih.gov/pubmed/38047026 http://dx.doi.org/10.7717/peerj.16314 |
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