Cargando…

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma

BACKGROUND: Metabolism reprogramming plays a vital role in glioblastoma (GBM) progression and recurrence by producing enough energy for highly proliferating tumor cells. In addition, metabolic reprogramming is crucial for tumor growth and immune‐escape mechanisms. Epidermal growth factor receptor (E...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Xiaoteng, Zhao, Jixing, Li, Guanzhang, Yang, Chao, Yang, Shixue, Zhan, Qi, Zhou, Junhu, Wang, Yunfei, Xiao, Menglin, Hong, Biao, Yi, Kaikai, Tong, Fei, Tan, Yanli, Wang, Hu, Wang, Qixue, Jiang, Tao, Fang, Chuan, Kang, Chunsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693308/ https://www.ncbi.nlm.nih.gov/pubmed/37920878 http://dx.doi.org/10.1002/cac2.12502

Ejemplares similares

TCA-phospholipid-glycolysis targeted triple therapy effectively suppresses ATP production and tumor growth in glioblastoma
por: Yang, Shixue, et al.
Publicado: (2022)

PTRF/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-κB/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma
por: Yi, Kaikai, et al.
Publicado: (2022)

PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma
por: Yang, Eryan, et al.
Publicado: (2022)

Expert opinion on translational research for advanced glioblastoma treatment
por: Cui, Xiaoteng, et al.
Publicado: (2023)

Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance
por: Zhou, Junhu, et al.
Publicado: (2023)

Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A
por: Jin, Weili, et al.
Publicado: (2022)

Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated Macrophage
por: Cui, Xiaoteng, et al.
Publicado: (2021)

Complete blockage of the mevalonate pathway results in male gametophyte lethality
por: Suzuki, Masashi, et al.
Publicado: (2009)

RUNX1 contributes to the mesenchymal subtype of glioblastoma in a TGFβ pathway-dependent manner
por: Zhao, Kai, et al.
Publicado: (2019)

Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma
por: Huang, Kai, et al.
Publicado: (2019)

Universal theranostic CRISPR/Cas13a RNA-editing system for glioma
por: Wu, Ye, et al.
Publicado: (2023)

Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein
por: Wang, Lin, et al.
Publicado: (2021)

Homotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma
por: Wang, Lin, et al.
Publicado: (2020)

Collateral Effects: The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells (Adv. Sci. 20/2019)
por: Wang, Qixue, et al.
Publicado: (2019)

The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells
por: Wang, Qixue, et al.
Publicado: (2019)

Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019)
por: Huang, Kai, et al.
Publicado: (2019)

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression
por: Zhao, Hongyu, et al.
Publicado: (2020)

LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF-κB activity, promoting tumorigenesis
por: Li, Yansheng, et al.
Publicado: (2021)

Editorial: The State-of-Art in Immuno-Oncology, What to Do With Glioblastoma?
por: Cui, Xiaoteng, et al.
Publicado: (2021)

A Compound AC1Q3QWB Selectively Disrupts HOTAIR-Mediated Recruitment of PRC2 and Enhances Cancer Therapy of DZNep
por: Li, Yansheng, et al.
Publicado: (2019)

lncRNA PRADX is a Mesenchymal Glioblastoma Biomarker for Cellular Metabolism Targeted Therapy
por: Xu, Can, et al.
Publicado: (2022)

Genomic landscapes by multiregion sequencing combined with circulation tumor DNA detection contribute to molecular diagnosis in glioblastomas
por: Yang, Chao, et al.
Publicado: (2019)

Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway
por: Wang, Qixue, et al.
Publicado: (2018)

Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells
por: Iizuka-Ohashi, Mahiro, et al.
Publicado: (2018)

HOTAIR Up-Regulation Activates NF-κB to Induce Immunoescape in Gliomas
por: Wang, Yunfei, et al.
Publicado: (2021)

Single-cell RNA-seq reveals RAD51AP1 as a potent mediator of EGFRvIII in human glioblastomas
por: Wang, Qixue, et al.
Publicado: (2019)

The synergic antitumor effects of paclitaxel and temozolomide co-loaded in mPEG-PLGA nanoparticles on glioblastoma cells
por: Xu, Yuanyuan, et al.
Publicado: (2016)

Effects of combined radiosurgery and temozolomide therapy on epidermal growth factor receptor and variant III in glioblastoma multiforme
por: Lin, Yiguang, et al.
Publicado: (2018)

FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury
por: Cai, Ying, et al.
Publicado: (2020)

Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells
por: Ma, Jian, et al.
Publicado: (2016)

Boosting of the enhanced permeability and retention effect with nanocapsules improves the therapeutic effects of cetuximab
por: Yang, Chao, et al.
Publicado: (2020)

Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide
por: Wang, Yan, et al.
Publicado: (2021)

Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome
por: Haas, Dorothea, et al.
Publicado: (2006)

Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models
por: Valtorta, Silvia, et al.
Publicado: (2017)

Diagnostic value of urinary mevalonic acid excretion in mevalonate kinase deficiency (MKD)
por: Jeyaratnam, Jerold, et al.
Publicado: (2014)

Genomic variations of the mevalonate pathway in porokeratosis
por: Zhang, Zhenghua, et al.
Publicado: (2015)

Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy
por: Zhan, Qi, et al.
Publicado: (2020)

The mevalonate coordinates energy input and cell proliferation
por: Gong, Li, et al.
Publicado: (2019)

Combinatorial engineering of hybrid mevalonate pathways in Escherichiacoli for protoilludene production
por: Yang, Liyang, et al.
Publicado: (2016)

Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways
por: Bruzzese, F, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_08q20ad6qgmjc6ok907tcd4vo7