Do multiple physiological OCT biomarkers indicate age-related decline in rod mitochondrial function in C57BL/6J mice?

PURPOSE: To test the hypothesis that rod photoreceptor mitochondria function in vivo progressively declines over time. METHODS: 2, 12, and 24 month-old dark- and light-adapted C57BL/6J (B6J) mice were examined by OCT. We measured (i) an index of mitochondrial configuration within photoreceptors meas...

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Detalles Bibliográficos
Autores principales: Goodman, Cole, Podolsky, Robert H., Childers, Karen Lins, Roberts, Robin, Katz, Ryan, Waseem, Rida, Paruchuri, Anuhya, Stanek, Josh, Berkowitz, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693340/
https://www.ncbi.nlm.nih.gov/pubmed/38046657
http://dx.doi.org/10.3389/fnins.2023.1280453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693340/
https://www.ncbi.nlm.nih.gov/pubmed/38046657
http://dx.doi.org/10.3389/fnins.2023.1280453

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