Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin

INTRODUCTION: Hepatotoxicity induced by immunotherapeutics is an appearing cause for immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to assess using current preclinical models and the incidence is too low to detect in clinical trials. As hepatotoxicity is a freq...

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Detalles Bibliográficos
Autores principales: Roser, Luise A., Luckhardt, Sonja, Ziegler, Nicole, Thomas, Dominique, Wagner, Pia Viktoria, Damm, Georg, Scheffschick, Andrea, Hewitt, Philip, Parnham, Michael J., Schiffmann, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693457/
https://www.ncbi.nlm.nih.gov/pubmed/38045689
http://dx.doi.org/10.3389/fimmu.2023.1275368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693457/
https://www.ncbi.nlm.nih.gov/pubmed/38045689
http://dx.doi.org/10.3389/fimmu.2023.1275368

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