The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells

Overcoming multidrug resistance (MDR) represents a major obstacle in cancer chemotherapy. Cardiac glycosides (CGs) are efficient in the treatment of heart failure and recently emerged in a new role in the treatment of cancer. ZINC253504760, a synthetic cardenolide that is structurally similar to wel...

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Detalles Bibliográficos
Autores principales: Zhou, Min, Boulos, Joelle C., Klauck, Sabine M., Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693532/
https://www.ncbi.nlm.nih.gov/pubmed/37322258
http://dx.doi.org/10.1007/s10565-023-09813-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693532/
https://www.ncbi.nlm.nih.gov/pubmed/37322258
http://dx.doi.org/10.1007/s10565-023-09813-w

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