Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesis

Quorum sensing is a mechanism of bacterial communication that controls virulence gene expression. Pseudomonas aeruginosa regulates virulence via two synthase/transcription factor receptor pairs: LasI/R and RhlI/R. LasR is considered the master transcriptional regulator of quorum sensing, as it upreg...

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Detalles Bibliográficos
Autores principales: Simanek, Kayla A., Schumacher, Megan L., Mallery, Caleb P., Shen, Stella, Li, Lingyun, Paczkowski, Jon E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693556/
https://www.ncbi.nlm.nih.gov/pubmed/38042853
http://dx.doi.org/10.1038/s41467-023-43702-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693556/
https://www.ncbi.nlm.nih.gov/pubmed/38042853
http://dx.doi.org/10.1038/s41467-023-43702-4

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