Enhanced TARP-γ8-PSD-95 coupling in excitatory neurons contributes to the rapid antidepressant-like action of ketamine in male mice

Ketamine produces rapid antidepressant effects at sub-anesthetic dosage through early and sustained activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), however, the exact molecular mechanism still remains unclear. Transmembrane AMPAR regulatory protein-γ8 (TARP-γ8)...

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Detalles Bibliográficos
Autores principales: Xue, Shi-Ge, He, Jin-Gang, Lu, Ling-Li, Song, Shi-Jie, Chen, Mei-Mei, Wang, Fang, Chen, Jian-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693574/
https://www.ncbi.nlm.nih.gov/pubmed/38042894
http://dx.doi.org/10.1038/s41467-023-42780-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693574/
https://www.ncbi.nlm.nih.gov/pubmed/38042894
http://dx.doi.org/10.1038/s41467-023-42780-8

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